Towards the identification of protein complexes and functional modules by integrating PPI network and gene expression data

Min Li¹ ²,Xuehong Wu¹ ,  Jianxin Wang¹ , Xiaoqing Peng¹, YiPan¹ ²
1 School of Information Science and Engineering, Central South University, Changsha, 410083, China
2 Department of Computer Science, Georgia State University, Atlanta, GA 30302-4110, USA.


Software download:  TSN-PCD.jar




The original protein-protein interaction data of S.cerevisiae, consisting of 4950 proteins and 21,788 interactions, was downloaded from the DIP database (2009, version12)( Static_network.txt

The gene-expressing profiles of S.cerevisiae were retrieved from Tu et al., 2005, which contains 6777 gene products and 36 samples in total, with 4,858 genes involved in the yeast PPI network. series_matrix.txt